Endocrine Abstracts

Introduction: β-cell function declines progressively in patients with type 2 diabetes (T2D). the fasting C-peptide/glucose ratio (Cp/G) is used for its evaluation. The GLP1 receptor agonist liraglutide improves glucose and weight control, presumably due to improvement of β-cell function and/or mass. This study evaluates the effect of a 6-months’ treatment with liraglutide in β-cell function, measured by Cp/G, in patients with obesity and T2D.<p class="a...

Langerhans cell histiocytosis (LCH) is a rare disease often involving the hypothalamo-pituitary axis. Extreme obesity is frequent, but effective treatment is not. Malabsorptive bariatric surgery techniques are effective for weight loss in hypothalamic dysfunction. Laparoscopic sleeve gastrectomy (LSG) has recently emerged as a restrictive bariatric procedure to be used before biliopancreatic diversion or gastric bypass, thus reducing surgery-associated morbidity in particularl...

Ceramides (Cer), which are known to be altered in plasma before the onset of coronary artery disease (CAD), have been proposed as new markers for cardiovascular disease (CVD) risk. Serum Cer18:1/C16:0, Cer18:1/C18:0 and Cer18:1/C24:1 to Cer18:1/24:0 indexes are proposed to be indicative of CAD. Epicardial adipose tissue (EAT) is a visceral adipose tissue, surrounding and in direct contact with the myocardium and coronary arteries, which volume is considered a risk factor for C...

Introduction: Bariatric surgery (BS) has emerged as the most effective treatment for severe obesity, but weight regain after surgery is an important issue. The aim of this study was to evaluate the impact of different surgical techniques on long-term dynamic weight loss pattern.Materials and methods: We retrospectively included 444 patients with BMI > 35 kg/m2 who underwent different BS techniques: Sleeve gastrectomy (SG; n: 80), ...

Introduction: Controversy exists regarding type 2 diabetes (T2D) remission rates after bariatric surgery (BS) due to heterogeneity in its definition and patients’ baseline features. We evaluate T2D remission using recent criteria, according to preoperative characteristics and insulin use.Materials and methods: Retrospective study from a cohort of 657 BS performed in a single centre (2006–2011) of which 141 (57.4% women) had T2D. Evaluation of a...

Introduction: Remission of type 2 diabetes (T2D) is a yearned outcome after bariatric surgery (BS). Attention to individuals who do not strictly fulfil remission criteria has been frequently left behind. The aim of this study was to evaluate metabolic control status in patients considered as diabetes ‘non-remitters’.Materials and methods: Retrospective study of 125 patients (59.2% women) with preoperative diagnosis of T2D who underwent BS in a ...

Introduction: Post-surgical hypoparathyroidism (PSHP) is a frequent complication following ENT surgery. Some patients with head/neck cancers require enteral nutrition (EN) due to dysphagia, mucositis after radiotherapy or chemotherapy, or post-surgical anatomical complications. Formulas of calcitriol are not suitable to be administered via enteral feeding tubes, and side effects of systemic antineoplastic treatment (nausea, vomiting) make calcium and phosphate serum levels dif...

Background: Bariatric surgery (BS) has proven to be an effective and sustainable long-term treatment in the remission of metabolic disorders. Bile acids (BAs) are involved in the improvement of metabolic comorbidities by acting on the distal ileum (releasing GLP1, PYY and FGF19) and on the microbiota. Our aim is to verify whether the formation of ABs depends on the type of bariatric surgery.Subjects and Methods: 21 patients (81% women) underwent bariatri...